Roger Williams

Roger is a structural biologist in the LMB Laboratory of Molecular Biology in Cambridge. A focus of his work is the activation of PI3K-superfamily of enzymes. His lab studies the structures, dynamics and functions of the PI3K superfamily and related pathways in cellular signalling, protein sorting, nutrition, organelle biogenesis and nerve regeneration. In addition to understanding PI3Ks and PIKKs in these processes, his lab are selecting and designing small molecules that exploit unique dynamics of these enzymes to activate them, for example, the PI3Kalpha activator 1938 that speeds nerve growth.